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Academic Programme
Implemented from September 2025
The molecules of life: from structure to chemical function (5 ECTS)
Semester 1
+
All courses during this semester
- Experimental methods on innovative research infrastructures - 5 ECTS
- Digital Micro-certification "The challenges of sustainable chemistry" - 10h
- Transferable skills : French language & interculturality (3 ECTS)
- Quantum mechanics towars quantum computing (5 ECTS)
- Winter school in Data Science (2 ECTS)
- Organic / Inorganic chemistry towards sustainability (5 ECTS)
- Kinetics and Electrochemistry (5 ECTS)
- Introduction to biophysics and microscopies for life science (5 ECTS)
Semester 2
+
All courses during this semester
- Luminescence spectroscopy of Lanthanides (3 ECTS)
- Summer School in Entrepreneurship (5 ECTS)
- Transferable skills: Polish course (3 ECTS)
- The molecules of life: from structure to chemical function (5 ECTS)
- Thermodynamics and soft matter (3 ECTS)
- Introduction to solid state (5 ECTS)
- Tech-infused perspectives on photochemical reaction dynamics (6 ECTS)
- Transferable skills: Portuguese course (3 ECTS)
- Summer School in Entrepreneurship (5 ECTS)
- Solid State Physics (5 ECTS)
- Molecular Energetics (3 ECTS)
- Laboratory of Materials and Surface Analysis (5 ECTS)
- Interfacial Electrochemistry (3 ECTS)
- Interfaces, Colloids and Self-Assembly (6 ECTS)
Semester 3
+
All courses during this semester
- 1-year research project - master thesis (equivalent 45 ECTS)
- Progress assessment of the research project (equivalent 6 ECTS)
- Weekly seminars (equivalent 4 ECTS)
- Special Topics in Chemistry (equivalent 5 ECTS)
- French language courses (3 ECTS)
- Nanosciences (6 ECTS)
- Medical applications of nanomaterials and radiations (6 ECTS)
- Top management, corporate law, and project writing for technology transfer and decision making (4 ECTS)
- Tracking ultrafast radiation-induced reactivity (3 ECTS)
- Applications for renewable energy and storage: solar fuels, batteries and hydrogen (6 ECTS) (6 ECTS)
- Scientific Writing and career objectives (2 ECTS)
- Surface Science and Nanostructuring at Surfaces (6 ECTS)
- Polymers for electronics and energy harvesting (5 ECTS)
- Electrochemical systems for fuel and electrolysis cells and batteries (6 ECTS)
- Project-based laboratory on device building (3 ECTS)
- Italian Courses (3 ECTS)
- Chemistry and Technology of Catalysis (5 ECTS)
Content
The students will understand how the atomic structure of biological molecules is discovered and how this knowledge is applied in modern drug discovery. If interested in this subject - they may continue their careers in the drug development industry.
Auditorium lectures
- Principles of protein structure.
- Classification of protein folds.
- Anatomy and taxonomy of nucleic acids and macromolecular complexes.
- Overview of experimental methods of structural biology: cryo-EM.
- Principles of macromolecular crystallography.
- Protein handling and crystallization.
- Phasing methods in macromolecular crystallography.
- Electron density maps and model building.
- Protein Data Bank (PDB) and model validation.
- Examples of structure-based drug design.
Laboratory practicals
- Protein handling and crystallization including robotic crystallization.
- Protein crystal handling, cryoprotection and X-ray diffraction experiments.
- Electron density maps and their interpretation.
- PDB and bioinformatics tools for protein analysis.
- An exercise in structure-guided drug design.
- Protein model building.
Journal club
- 5 meetings with student seminars presenting assignments from current literature with discussion.
Aims
The students will understand how the atomic structure of biological molecules is discovered and how this knowledge is applied in modern drug discovery.
Recommended Books
- Gale Rhodes, Crystallography Made Crystal Clear, 3rd edition, Academic Press, Amsterdam 2006.
- Bernhard Rupp, Biomolecular Crystallography, Garland Science, New York 2010.
- Arthur Lesk, Introduction to Protein Science, Oxford University Press 2010.
- Carl Branden & John Tooze, Introduction to Protein Structure, 2nd edition, Garland Publishing, New York 1996.
Teaching Staff
Prof. Mariusz Jaskolski
Dr. Szymon Krzywda
Hours
Lectures: 15h
Practical: 30h